Subscribe to Newsletter
Fields & Applications Pharma & Biopharma, Mass Spectrometry, Metabolomics & Lipidomics

Advancing molecular glue discovery through high throughput Mass spectrometry based proteomics on Orbitrap Astral mass spectrometer

sponsored by Thermo Fisher Scientific

Register now

The field of Targeted Protein Degradation (TPD) has emerged as a new therapeutic modality to harness the ubiquitin-proteasome system for targeting proteins that were once considered undruggable through the traditional inhibitor-based modalities. 

TPD primarily relies on heterobifunctional molecules like proteolysis-targeting chimeras (PROTACs) and molecular glues to bring the target proteins into proximity to the ubiquitin-proteasome system to induce protein degradation. 

Molecular glues are monovalent small molecules with drug-like properties that alter the protein binding surface of E3 ligase, resulting in novel E3 ligase and target protein interactions. Molecular glues are difficult to design and are often discovered retrospectively. 

The rational design and discovery of molecular glues require an untargeted approach to understand the protein ternary complexes, target protein degradation, and ubiquitination induced by potential molecular glues. 

We have leveraged untargeted, high-throughput proteomic approaches to better understand protein-protein interactions and target protein degradation induced by prospective molecular glues. 

The recent developments in the field of high-throughput proteomics due to the introduction of faster and more sensitive mass spectrometers have brought us closer to the rational design and discovery of molecular glues.

Webinar learning objectives:

  • The use of mass spectrometry to perform Targeted Protein Degradation (TPD) studies.
  • Use of high-throughput proteomic approaches to better understand protein-protein interactions and target protein degradation induced by prospective molecular glues.
  • Learn about the novel Orbitrap Astral Mass Spectrometer and it's capabilities.

Register now

Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Related Application Notes
Reproducible oligonucleotide IEX analyses from the very first injection!

| Contributed by YMC

Separation of plasmid isoforms using BioPro HIC BF

| Contributed by YMC

Enabling 3D Multiplexing Spatial Omics Workflows in Neuroscience

| Contributed by Zeiss

Related Product Profiles
Higher Peaks – Clearly.

| Contributed by Shimadzu Europa

Compact with countless benefits

| Contributed by Shimadzu Europa

The fine Art of Method Development

| Contributed by Shimadzu Europa

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register