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Comprehensive Screen of Acidic/Neutral/Basic Drugs from Urine and Plasma using Micro-Prep® HLB Extraction Plate & Analysis on LC-MS/MS


Analytical Toxicology involves methods for comprehensive screening of biological matrices for the presence abused drugs. Routine analysis of samples in clinical and forensic settings demands quick and efficient extraction procedures. Smaller sorbent amounts utilized by Solid Phase Extraction (SPE) products allow scaling-down of starting sample size and minimize the total solvent volumes required to wash matrix components and elute the target analytes. 2 mg or less of sorbent particles embedded in a disc membrane allows for sample enrichment and high throughput processing. As compared to lose sorbent, disk format eliminates channeling effects and reduces dead volume. Removal of the evaporation step from the procedure also decreases overall turn-around time.

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