The spine-tingling story behind megavolt electrostatic ionization mass spectrometry

Work performed in conjunction with the Institut Pasteur, Paris, France Cations are specifically recognized by numerous proteins. Despite their small size, their specific interactions with highly charged residues allow them to induce significant conformational changes on their binding proteins.

Whey is a by-product of the cheese-making process, and Whey Protein Isolate (WPI) is a dietary supplement and food ingredient created by separating components from milk. It contains a high percentage of pure protein and can be pure enough to be virtually lactose free, carbohydrate free, fat free, and cholesterol free. In this application note, a sample of WPI was characterized using the Viscotek TDAmax. The 4 main components in this mixture were separated and individually characterized.

This application note presents an example of how calorimetry aided the formulation development for ProX by providing insight into excipient-protein interactions. Polysorbate-80 and phenol are examined here as potential additives to the formulation buffer for ProX.

The study of exosomes and other cell-derived microvesicles is an area of rapidly rowing importance and the subject of intense interest and research. The previous lack of suitable methods for their detection, analysis, enumeration and phenotyping is proving to be a significant limitation in these studies. This document shows the degree to which the technique of Nanoparticle Tracking Analysis (NTA) is helping to address these problems.

Analytical QbD (AQbD) promises to extend the rigor and benefits of QbD into the area of analytical method development.

Showcasing the greatest analytical advances of the year

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Micrograph of ionic liquid microarrays fabricated on a gold surface.

Earwax – or cerumen – comprises secretions from specialized sweat glands and fatty materials produced by sebaceous glands.