Charge heterogeneity characterisation of an IgG4-based mAb using AEX coupled to MS

contributed by YMC | 01/26/2024

Cation exchange chromatography (CEX) is very well suited for characterising the charge heterogeneity of biomolecules. This also applies to most commercially available monoclonal antibodies (mAbs). They are often based on IgG1 and have a high isoelectric point (pI). Anion exchange chromatography (AEX), has so far only been used for relatively acidic proteins.

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