Charge heterogeneity characterisation of an IgG4-based mAb using AEX coupled to MS

contributed by YMC | 01/26/2024

Cation exchange chromatography (CEX) is very well suited for characterising the charge heterogeneity of biomolecules. This also applies to most commercially available monoclonal antibodies (mAbs). They are often based on IgG1 and have a high isoelectric point (pI). Anion exchange chromatography (AEX), has so far only been used for relatively acidic proteins.

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

Receive communication from The Cannabis Scientist I want to stay up to date with the Mass Spectrometry field I want to stay up to date with the Spectroscopy field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.