YMC

(U)HPLC analysis of siRNA under denaturing and non-denaturing conditions using IP-RP and AEX

The phospholipids LPC (16:0) and PC (34:2) are analysed in plasma by UHPLC-MS.

3 oligonucleotide mixtures are analysed using a bioinert coated YMC-Accura Triart Diol-HILIC column.

The purity of a crude single stranded 20mer DNA is obtained using a YMC-Triart C18 UHPLC column.

mRNA coupled to EGFP is analysed using two bioinert columns: the widepore RP column YMC-Accura Triart Bio C4 the and non-porous BioPro IEX QF column

Molnupiravir and β-d-N4-hydroxycytidine- separated by using a YMC-Triart C18 UHPLC column and a MS mobile phase (pH 4.3) at temperatures of 40°C

Five short- and long-term markers with very different hydrophobicity were analysed using RP and HILIC mode.

HILIC is the perfect choice for a fast separation of hydrophilic dipeptides, with well-resolved peaks of 4 dipeptides in less than 4 minutes.

A YMC-Triart C18 and a YMC-Triart SIL column are used in RP and NP mode respectively for the analysis of four different phosphoramidites.

Small peptides are analysed using UHPLC conditions. As the analyses require pH values up to pH 9 and elevated temperatures, the outstanding robust YMC