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Proteomics

Techniques & Tools Proteomics

The Old Guard

| Rich Whitworth

Sitting Down With Fred McLafferty, Professor Emeritus at Cornell University

Techniques & Tools Mass Spectrometry

Three Gurus of Proteomics

| Christian Huber, Barry Karger, John Yates

Proteomics is all the rage. Here, three leaders in the field – Christian Huber, Barry Karger and John Yates – go beyond the hype to discuss where the field is going and what might hold progress back

Fields & Applications Mass Spectrometry

March of Progress

| André Deelder

Where does clinical bio-molecular mass spectrometry (MS) sit on the steep slope between hype and hope?

Fields & Applications Technology

Orbitrap Against All Odds

| Alexander Makarov

The development of Orbitrap™ has taken up all of my professional life. It’s been a story of luck, perseverance, occasional deep insight and, ultimately, success.

Fields & Applications Mass Spectrometry

The Distinguished Scientist

| Rich Whitworth

Richard D. Smith, Chief Scientist of the Biological Sciences Division at Pacific Northwest National Laboratory, reflects on 40 years in mass spectrometry following his Distinguished Contribution award at ASMS 2013.

Fields & Applications Mass Spectrometry

Cracking the Epigenetic Code

| Pawel Olszowy

Mass spectrometry (MS) approaches are increasing our understanding of how DNA is regulated in real life.

Techniques & Tools Liquid Chromatography

Slip Flow Star

| Mary Wirth

The use of submicrometer particles in chromatography, viewed as heresy when first suggested a decade ago, is today seen as a possible quantum leap in separation efficiency. This is a first‑hand account of the origins of the idea, the experiments that yielded crystal-clear data and the literature on slip flow that provided an explanation of the remarkable findings.

Fields & Applications Mass Spectrometry

Wound Healing in Diabetes

| Rich Whitworth

Applying an inclusive analysis that requires minimal sample manipulation to generate robust biomolecular signatures from diabetic wound fluid

Techniques & Tools Proteomics

Immune System Chat Room

| Rich Whitworth

How hundreds of extracellular signaling proteins secreted during immune responses were ... discovered – and what it tells us about the whisperered conversations between cells

Fields & Applications Mass Spectrometry

Structural Proteomics Takes Aim at Disease

| Amrita Mitra, Amit Kumar Mandal

A combination of HDX-MS and IMS will help to explore the basis of functional failures in proteins linked to medical ... conditions.

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