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Sensors

Techniques & Tools Sensors

A Nose for Quality

| Victoria Barton

Sniffing out ‘off smells’ in drinking water with a bioelectronic sensor

Fields & Applications Sample Preparation

Nanoparticle Tracking Analysis: Drug nanocarriers

The role that nanoparticles play in the rapidly developing field of ‘NanoMedicine’ has been discussed previously in Chapter 5. In this Chapter, we review the specific mechanisms by which such nanoparticles are designed and formulated and in which NTA has had a significant part to play.

Fields & Applications Sample Preparation

Monitoring the particle size distribution of ground coffee

The ability to quickly and reproducibly measure coffee ground particle size and size distributions is important during grinding operations to ensure that the coffee quality is maintained and that the correct grade is produced. The Mastersizer 3000 and the Funnel Sample Feeder for the Aero S dry powder disperser provides this capability, offering a rapid alternative to traditional sieve analysis.

Fields & Applications Sample Preparation

Microcalorimetry as a tool for structural biology

Learn how Isothermal titration calorimetry can be used to guide protein (RNA)/ligand crystallization and to resolve common issues with crystallization of complexes.

Fields & Applications Sample Preparation

Protein stability measurements amplified: Combining SEC-MALS and DLS to maximize data output

The stability of a protein sample and its tendency to aggregate is explored using a combination of SEC-MALS and DLS

Fields & Applications Sample Preparation

Accelerating the deformulation workflow for oral solid dosage forms

In this white paper we examine the deformulation workflow, demonstrating the value of the technique of Morphologically Directed Raman Spectroscopy (MDRS) within this context. Case studies illustrate the relevance of MDRS data.

Fields & Applications Sample Preparation

Detecting agglomerates within pharmaceutical formulations

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides practical guidance on how imaging can be applied as a routine method to robustly identify and quantify the state of agglomeration of pharmaceutical formulations.

Fields & Applications Sample Preparation

Detecting the Presence of Anomalous Large Particles within Powders Using Laser Diffraction Particle Size Analysis

In some industries, for example, in early-stage pharmaceutical development, it is desirable to measure particle size from a small samples of dry powders. However measuring small quantities risks measuring a sample that is not representative of the bulk material. In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.

Techniques & Tools Technology

Spectrometry Take Flight

| Stephanie Vine

Aerial drones already aid in sample collection. Is in-situ water analysis next?

Techniques & Tools Technology

Return of the TASIAs

| Rich Whitworth

Accurate measurement drives progress in science in immeasurable ways. Here, we celebrate a year’s worth of advances in The Analytical Scientist Innovation Awards 2014. What impact will these 15 TASIA winners have on your field?

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