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Fields & Applications Pharma & Biopharma, Genomics & DNA Analysis

Quantify Viral Vector Attributes with Light Scattering

sponsored by Wyatt Technology

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March 1st 11AM EDT, 8AM PDT

Adeno-associated virus (AAV) is a common delivery vehicle in gene therapy. Robust, rapid and automated characterization methods are imperative for commercialization of AAV-based products. However, standard methods are labor- and time-intensive, requiring costly reagents. In this presentation, we will discuss a method to measure three critical quality attributes (CQAs) of AAVs: 1) total number of viral capsid particles; 2) relative capsid content (e.g., fraction of full capsids); and 3) percentage of monomer or aggregates. The highly precise SEC-MALS method utilizes multi-angle light scattering in line with standard size-exclusion chromatography, requiring little sample prep, no reagents and minimal operator effort.

Learning objectives:

  • How light scattering combines with SEC and other detectors to provide comprehensive biophysical analysis of AAVs
  • How SEC-MALS can be positioned as a platform technology in AAV development and production

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