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EP/USP GPC/SEC Molar Mass Determination for Low Molecular Weight Heparin (LMWH)

LMWHs are defined as heparin salts having an average molecular weight of less than 8000 Da. Both, the Pharmaeuropa and the US Pharmacopeia, require GPC/SEC to characterize e.g. Enoxaparin Sodium or other low molar mass heparins with respect to molecular weight. A dedicated GPC/SEC software such as PSS WinGPC UniChrom is required to obtain reliable mass fraction information.

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