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Genomics & DNA Analysis

Techniques & Tools Proteomics

Proteomics to the People

| Joanna Cummings

A beautiful video ‘sells’ the fascinating world of large-scale proteome studies

Techniques & Tools Forensics

Forensics: The Next Generation

| Bruce McCord

How will modern genomics tools and other analytical breakthroughs drive forensic science?

Fields & Applications Genomics & DNA Analysis

G-A-T-T-A-C-A

| Rich Whitworth

Imagine a society where people are discriminated against due to genetic predisposition to disease…

Fields & Applications Genomics & DNA Analysis

Name Your Poison

| Roisin McGuigan

A new DNA-based sensor shows promise for indirect detection of thallium

Fields & Applications Genomics & DNA Analysis

Gold Rush

| Rich Whitworth

Nanoporous gold helps ‘sieve out’ biological debris for fuss-free nucleic acid detection

Fields & Applications Technology

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies Choosing the best antibody to progress in your biologic pipeline. Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments. Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline.

Fields & Applications Mass Spectrometry

Splitting Hairs

| Bryn Flinders

Despite the recent bad press, cutting-edge analytical techniques are transforming the field of hair analysis

Techniques & Tools Mass Spectrometry

Holistic Bioanalytics

| Rich Whitworth

Lawrence (Larry) Lesko is a bioanalytical veteran with many years of academic and FDA experience. Now, as director of the University of Florida’s Center for Pharmacometrics and Systems Pharmacology, Larry uses metabolomics to discover biomarkers of drug toxicity.

Techniques & Tools Liquid Chromatography

Marking Progress

| Monika Dittman, Fabrice Gritti

Monika Dittman (Agilent Technologies) and Fabrice Gritti (Waters) offer a manufacturer point of view on the practical limits of LC.

Fields & Applications Liquid Chromatography

Marching Ever Onward

| Gert Desmet

The evidence contradicts those who say liquid chromatography has fully matured.

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