Pharma & Biopharma

The investigative power of multiple detectors. Here, we describe the analysis of a semi-purified protein mixture containing β-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how coupling this data can be qualitatively and quantitatively evaluated.

Compact Spark spectral sensor measures Vis-NIR absorbance of hemoglobin – and more

Analysis of chlorhexidine drug substance using an Agilent 6545 Accurate Mass Q-TOF System and MassHunter Mass Profiler Software.

The traditional approach of designing experiments by changing one factor at a time is outmoded.

The analytical world in general has yet to appreciate the power of FTIR spectroscopic imaging for process analysis. Here’s why it should be in your toolkit.

The molecular weight, molecular weight distribution and size of two common polymers are measured using SEC-MALS 20. Results from SEC-MALS and conventional calibration are compared and discussed.

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Learn why isothermal titration calorimetry is a method of choice for accurate and precise determination of critical micellar concentration of surfactants for biochemical applications and find out how to analyse demicellization data from Isothermal Titration Calorimetry

Usually, PLA and PLGA are based on monomers from renewable sources, so are considered “green” polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.

This application note will describe the analysis of a series of dextran samples ranging in molecular weight from about 1 – 650 kDa. Structural comparisons to other polysaccharides, gum arabic and pectin are presented. Initially discovered by Louis Pasteur in 1861, dextran is a polysaccharide that has found a variety of applications, primarily in the medical field, due to its minimal side-effects and solubility in aqueous media.