Working hard to achieve other people's goals - a sentiment that defines the analytical sciences.

This whitepaper reviews the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation / size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the principles discussed are equally applicable to proteins or protein conjugate materials.

This white paper offers practical guidance on using a range of analytical techniques, including rheology, particle size and zeta potential measurement to assist in the formulation of Inkjet inks.

Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.

The complementarities of two techniques, dynamic light scattering (DLS) and static light scattering detector coupled with a size exclusion chromatography system (SEC-LS), are illustrated by studying a number of samples where a thermally denatured and aggregated protein sample were dosed at different levels into a non-denatured protein sample.

In this application note, intrinsic viscosity measurements were performed on the sRAGE protein to establish whether the detector was able to detect and characterize the conformational change induced by the presence of calcium. Light scattering molecular weight measurements were also performed. Data are also presented showing that the conformation of sRAGE changes in the presence and absence of calcium.

NASA scientists examine a microshutter array installed on Near-Infrared Spectrograph (NIRSpec)

Then & Now, with Stuart Adams, Higher Analytical Chemist at Fera Science Ltd, York, UK

We chat to Gary Christian, Emeritus Professor of Chemistry, University of Washington, USA

Don't let fear prevent you from progressing in your scientific career -take a leap of faith!