Liquid Chromatography

Time to take the plunge with supercritical fluid chromatography in bioanalytical applications

Will aerosol-based detectors ever meet all the needs of the pharmaceutical industry?

Get the most out of Pittcon, Atlanta with our top picks from the sessions.

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also increased amounts of information, which is made available by the combination of different detectors (and unobtainable using individual detectors separately). The theory of triple detection GPC/SEC is described here.

This application note describes the analyses of a variety of aqueous (water-soluble) cellulose derivatives using the OMNISEC triple detection system and the subtle, yet distinct differences between these different derivatives that can be parsed out by the OMNISEC system

In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied.

Analysis of chlorhexidine drug substance using an Agilent 6545 Accurate Mass Q-TOF System and MassHunter Mass Profiler Software.

Two-dimensional mass spectrometry (2DMS) can be twice as fast as conventional methods in proteomic analyses

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Continual advances in liquid chromatography have raised the bar from high performance to ultra-high performance, resulting in increased analytical, instrument, and laboratory efficiency. What’s holding you back from investments in UHPLC technology?