Techniques & Tools Pharma & Biopharma, Mass Spectrometry

Therapeutic Drug Monitoring Research using High Resolution Mass Spectrometry

Therapeutic drug monitoring (TDM) is important due to its impact on treatments and disease management.

12/20/2017

sponsored by Thermo Fisher Scientific

Therapeutic drug monitoring (TDM) is important due to its impact on treatments and disease management. TDM research of antidepressants is critical to ensure compliance and to rule out pharmacokinetic abnormalities such as rapid metabolizer genotype or drug interactions.

Therefore, new, reliable monitoring methods are essential for the optimization of drug therapies. While most of the current mass spectrometry methods use a triple quadrupole mass analyser, in this webinar we will discuss development of an analytical research method for the quantitation of 31 antidepressants using a high resolution Orbitrap ™ mass spectrometer.

Pharmacokinetic analysis of large antidepressants panel using Orbitrap™ High Resolution Mass Spectrometry.
Chromatographic separation of isobaric compounds in serum.
Reduction of matrix effects using TurboFlow online sample clean up.
Comparison of high resolution LC-MS to triple quad LC-MS.

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