Accurate Biological Testing for Amphetamine and Methamphetamine Abuse Using Chiral HPLC and MS Detection

contributed by Supelco | 09/23/2015

In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.

Methamphetamine and amphetamine, powerful CNS stimulants that have a variety of ethical uses, have side effects of increased confidence, sociability, and energy that have resulted in their extensive abuse as recreational psychoactive drugs. This extends to their abuse in sports because of the additional properties of increased mental alertness and suppression of fatigue.¹ Negative side effects include hypertension and tachycardia. In the usually uncontrolled situations of drug abuse, they exhibit similar psychoactive effects, although amphetamine is generally less potent than methamphetamine.

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