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YMC

Application Notes by YMC

Separation of oligonucleotides modified with disulfides using YMC-Triart Bio C4

| Contributed by YMC

Antisense DNA and siRNA are widely used for gene silencing in research and medical applications.

Fast UHPLC analysis of commercial monoclonal antibodies at elevated temperatures using YMC-Triart Bio C4

| Contributed by YMC

Monoclonal antibodies (MAbs) are immunologically active proteins, which bind specifically to certain cells or proteins.

ADC Analysis with LC-MS compatible mobile phases

| Contributed by YMC

In this application YMC-Triart Bio C4 was used to analyse a reduced monoclonal antibody and a reduced ADC mimic with formic acid or TFA as additives.

Method Development for Analysis of Amyloid Beta Proteins

| Contributed by YMC

Amyloid β (Aβ) are peptides of 36–43 amino acids that are derived from the amyloid precursor protein (APP) by cleavage with β- and γ- secretase.

Generic Analyses of Different Monoclonal Antibodies Using YMC-Triart Bio C4

| Contributed by YMC

Monoclonal antibodies (MAbs) are immunologically active proteins, which bind specifically to certain cells or proteins.

LC-MS/MS Analysis of Sphingophospholipids Using a Metal-free Column

| Contributed by YMC

Sphingolipids are major components forming biological membranes, and they serve as intracellular signalling molecules.

Optimisation of Oligonucleotide Separations - BioPro IEX QF

| Contributed by YMC

In this report, useful tips for optimisation of ion exchange chromatography methods for oligonucleotides are provided.

HIC Analysis of Different MAbs Using IPA and BioPro HIC BF by YMC

| Contributed by YMC

Monoclonal antibodies (MAb) are immunologically active proteins.

Analysis of benzodiazepines and their metabolites by UHPLC-MS/MS

| Contributed by YMC

Challenging simultaneous analysis of Amyloid β (Aβ) proteins

| Contributed by YMC

Aβ peptides are highly hydrophobic which leads to the formation of aggregates.

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