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Materials

Techniques & Tools Sample Preparation

Solvent Enhanced Light Scattering of Fluoro-Polyester

| Sponsored by Malvern Panalytical

Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.

Business & Education Sample Preparation

Intrinsic viscosity measurements on sRAGE protein

| Sponsored by Malvern Panalytical

In this application note, intrinsic viscosity measurements were performed on the sRAGE protein to establish whether the detector was able to detect and characterize the conformational change induced by the presence of calcium. Light scattering molecular weight measurements were also performed. Data are also presented showing that the conformation of sRAGE changes in the presence and absence of calcium.

Techniques & Tools Sample Preparation

The Benefits of Multi-Detector SEC for Protein Analysis'

| Sponsored by Malvern Panalytical

This article explores how multiple detectors, particularly light scattering detectors, may be used for size-exclusion chromatography (SEC) in protein analysis. Using a light scattering detector as part of a multi-detector Size Exclusion Chromatography system provides the accurate molecular weight (MW) data needed to assess the activity, safety and clinical efficacy of therapeutic proteins.

Fields & Applications Sample Preparation

Sizing up the Solution

This article explores the role of different components within drilling muds, including barite and calcium carbonate. The need to achieve optimum particle sizes is examined, the application of laser diffraction is considered within this context. Fast, efficient and having a wide measurement range, laser diffraction delivers accurate, precise and reproducible particle size information. Offering automated analysis, it is a preferred method for drilling mud particle sizing and the focus of ongoing API efforts to develop a standard in this area.

Fields & Applications Sample Preparation

Ten Ways to... Control Rheology by Changing Particle Properties

The newest addition to the popular ‘10 ways to…’ series of educational papers provides practical guidance on developing high performance suspension products with enhanced consumer appeal. ‘10 ways to...control rheology by changing particle properties’ explores how controlling particle characteristics, such as particle size distribution, concentration and zeta potential, enables formulators to engineer suspension performance. Suspensions are used in the formulation of a wide range of every day products from medicines, drinks and foodstuffs to paints, inks and coatings. This paper is therefore valuable to formulators working across a wide range of industries.

Techniques & Tools Sample Preparation

Optimizing Food Additive Choice: Exploring the Value of Recent Advances in SEC Technology

| Sponsored by Malvern Panalytical

The latest advances in the widely used technique of size exclusion chromatography (SEC) break new ground in terms of accuracy and sensitivity. This article assesses the information provided by multi-detector SEC and the potential benefits of recent innovations for polymeric food additive characterization.

Fields & Applications Sample Preparation

Identification of foreign particulate matter using the Morphologi G3-ID

The Morphologi G3-ID enables simultaneous physical and chemical characterization of particle samples, enabling outlier particles to be identified as being part of a product formulation or genuine foreign particle contaminants.

Techniques & Tools Sample Preparation

Solvent Enhanced Light Scattering Technique Enhances Gel Permeation Chromatography Analysis

| Chris Mirley, Sean Daughtry, Wei Sen Wong

The ideal solvent for a material may not provide a sufficient refractive index difference for light scattering detection. This example of a biodegradable polymer shows how SELS is used to increase dn/dc to give enhanced detection sensitivity

Techniques & Tools Sample Preparation

Assessing the effect of formulation composition on spidroin charge and stability

| Sponsored by Malvern Panalytical

This application note describes the use of a Zetasizer Nano ZSP to characterize the charge state of spidroins in different formulations. The earliest stages of spidroin aggregation in different formulations are then assessed using low-temperature synamic light scattering (DLS) thermal trend experiments.

Techniques & Tools Sample Preparation

Case study: Effects of gamma-ray sterilization on high molecular weight

| Baljit Ghatora

A sample of PMMA was analysed by Size Exclusion Chromatography with Triple detection, before and after sterilization. Reduction in the molecular weight was shown to be firstly by cleaving the polymer at the branching points.

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