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Materials

Techniques & Tools Sample Preparation

Case study: Effects of gamma-ray sterilization on high molecular weight

| Baljit Ghatora

A sample of PMMA was analysed by Size Exclusion Chromatography with Triple detection, before and after sterilization. Reduction in the molecular weight was shown to be firstly by cleaving the polymer at the branching points.

Techniques & Tools Sample Preparation

Viscotek SEC-MALS 20 to measure protein aggregation

| Sponsored by Malvern Panalytical

In this application note, a selection of proteins are separated using Size Exclusion Chromatograpghy (SEC). The molecular weights of their oligomers and aggregates are measured by SEC-MALS and the results discussed.

Fields & Applications Materials

Bringing MOFs Down to Size

| James Strachan

MOFs can now be nano-fabricated - what impact could the materials have on analytical science?

Techniques & Tools Sample Preparation

Principles of Triple Detection GPC/SEC

| Sponsored by Malvern Panalytical

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also increased amounts of information, which is made available by the combination of different detectors (and unobtainable using individual detectors separately). The theory of triple detection GPC/SEC is described here.

Techniques & Tools Mass Spectrometry

End of the Road

| James Strachan

Researchers use SPME and GC-MS to puncture claims that banned tire treatments are “undetectable”

Fields & Applications Materials

Gene Genie

Genomics platform director tops Thomson Reuters’ list of highly cited authors

Fields & Applications Sample Preparation

Analysis of demicellization data from isothermal titration calorimetry

Learn why isothermal titration calorimetry is a method of choice for accurate and precise determination of critical micellar concentration of surfactants for biochemical applications and find out how to analyse demicellization data from Isothermal Titration Calorimetry

Fields & Applications Spectroscopy

Analysis of different of PLA/PLGA polymer samples using a GPC/SEC system

Usually, PLA and PLGA are based on monomers from renewable sources, so are considered “green” polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.

Fields & Applications Spectroscopy

Using OMNISEC Triple-Detection GPC to Determine Structure of Dextrans and Other Polysaccharides

This application note will describe the analysis of a series of dextran samples ranging in molecular weight from about 1 – 650 kDa. Structural comparisons to other polysaccharides, gum arabic and pectin are presented. Initially discovered by Louis Pasteur in 1861, dextran is a polysaccharide that has found a variety of applications, primarily in the medical field, due to its minimal side-effects and solubility in aqueous media.

Fields & Applications Sample Preparation

Nanoparticle Tracking Analysis: Drug nanocarriers

The role that nanoparticles play in the rapidly developing field of ‘NanoMedicine’ has been discussed previously in Chapter 5. In this Chapter, we review the specific mechanisms by which such nanoparticles are designed and formulated and in which NTA has had a significant part to play.

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