Mass Spectrometry

Sitting Down With… Detlef Günther, VP Research and Corporate Relations, and Professor for Trace Element and Micro Analysis, ETH Zürich, Switzerland.

Coupling whole column imaging detection to a mass spectrometer for protein structure characterization is fundamentally challenging. Could a relatively simple capillary cartridge system unlock the potential?

Capillary electrophoresis-mass spectrometry (CE-MS) appears to be caught in a dichotomy – proven success in some fields, skepticism in others.

A growing target list, increasingly complex matrices, and the need for low limits of detection can make our field seem like an uphill treadmill.

Thin-layer chromatography’s ability to simply and inexpensively provide high-quality separations in parallel makes it the perfect partner for MALDI mass spectrometry

Can R&D organizations really afford to kill off analytical data that could be used for future decision-making? Perhaps it’s time to breathe life back into analytical data environments.

The juxtaposition of simplicity through new technology with complexity in the chemistry keeps gas chromatographic method development exciting – despite GC being described by many as a “mature” technique. But are we still using packed-column thinking?

Just imagine how many analytical problems would be solved if we could increase the resolution of liquid chromatography (LC) from hundreds to thousands or perhaps a hundred thousand compounds?

Online hyphenation of capillary electrophoresis and mass spectrometry is nearly 30 years old, but has been ignored in certain camps. It’s time to give CE-MS a chance.

Is the heat applied in gas chromatography-mass spectrometry really responsible for false results? And, if so, how often?