Technology

At ASMS 2015, GC-Orbitrap™ technology was unleashed onto an expectant analytical community. Here’s the backstory.

Raman spectroscopy has evolved into a powerful characterization technique for many applications. What more needs to be done to make it effective in clinical analysis?

The 2014 Nobel Prize in Physics, awarded “for the invention of efficient blue light-emitting diodes,” has put LEDs under the spotlight, particularly as a stable, robust and efficient light source in analytical sciences.

In this application note, we'll describe the successful molecular weight measurement of a polystyrene, PMMA and PVC sample using the OMNISEC system. This instrument can accurately measure the absolute molecular weight of any polymers independent of elution volume or structure. Although the measurements here have been performed using simple polymers, these methods can be applied to any polymer measured by GPC.

In the quest for increased sensitivity or higher resolution, let’s not lose sight of our objectives.

In this white paper we examine the deformulation workflow, demonstrating the value of the technique of Morphologically Directed Raman Spectroscopy (MDRS) within this context. Case studies illustrate the relevance of MDRS data.

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides practical guidance on how imaging can be applied as a routine method to robustly identify and quantify the state of agglomeration of pharmaceutical formulations.

My love of biology, mass spectrometry and computer programming has led me down an uncommonly rewarding path of discovery and innovation. Here, I share some of my story and look towards the horizon of my exciting and ever-changing field.

David Duffy, Ulf Landegren, Antoine van Oijen, and Menno Prins crash through the concentration barrier and investigate the ultimate limit of analytical sensitivity.

I find myself attempting a graceful “glissando” into greying semi-retirement. And what better way (other than Volvo-driving) to add gravitas and prestige than by teaching?