Clinical

...the perfect companion to The Analytical Scientist.

Sitting Down With... Waseem Asghar, winner of the 2016 Humanity in Science Awards

For over 50 years, we have been continually striving to push the limits of quantitation for dioxins. But where do we stand today – and what’s our next plan of attack?

Ion chromatography uncovers a link between low iodine levels and symptoms of autism

Are wasp-inspired needles the neurosurgery of the future?

MOFs can now be nano-fabricated - what impact could the materials have on analytical science?

Every year sees new chemicals added to the list of analytes that may need to be measured in a given sample. At the same time, environmental levels of many older pollutants may be in decline – but still must be measured.

Sitting Down With… Detlef Günther, VP Research and Corporate Relations, and Professor for Trace Element and Micro Analysis, ETH Zürich, Switzerland.

Optimizing oxygen delivery improves stem cell treatment of peripheral artery disease.

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies Choosing the best antibody to progress in your biologic pipeline. Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments. Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline.