Genomics & DNA Analysis

Cancer is incredibly complex, posing enormous challenges beyond the biological field. Taking a multi-omic approach can help us make sense of this diverse set of diseases – and, ultimately, allow us to better understand ourselves as human beings.

Researchers at the Dresden University of Technology can now determine the sex of a chicken before it hatches – in under a minute.

A beautiful video ‘sells’ the fascinating world of large-scale proteome studies

How will modern genomics tools and other analytical breakthroughs drive forensic science?

Imagine a society where people are discriminated against due to genetic predisposition to disease…

A new DNA-based sensor shows promise for indirect detection of thallium

Nanoporous gold helps ‘sieve out’ biological debris for fuss-free nucleic acid detection

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies Choosing the best antibody to progress in your biologic pipeline. Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments. Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline.

Despite the recent bad press, cutting-edge analytical techniques are transforming the field of hair analysis

Lawrence (Larry) Lesko is a bioanalytical veteran with many years of academic and FDA experience. Now, as director of the University of Florida’s Center for Pharmacometrics and Systems Pharmacology, Larry uses metabolomics to discover biomarkers of drug toxicity.