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Pharma & Biopharma

Techniques & Tools Sample Preparation

Using OMNISEC to Understand the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives

| Sponsored by Malvern Panalytical

This application note describes the analyses of a variety of aqueous (water-soluble) cellulose derivatives using the OMNISEC triple detection system and the subtle, yet distinct differences between these different derivatives that can be parsed out by the OMNISEC system

Techniques & Tools Sample Preparation

Case study of a semi-pure β-amylase extract

| Sponsored by Malvern Panalytical

The investigative power of multiple detectors. Here, we describe the analysis of a semi-purified protein mixture containing β-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how coupling this data can be qualitatively and quantitatively evaluated.

Fields & Applications Spectroscopy

Small-footprint Absorbance System for Characterizing Heme Proteins

| Yvette Mattley

Compact Spark spectral sensor measures Vis-NIR absorbance of hemoglobin – and more

Techniques & Tools Mass Spectrometry

Screening, Identifying, and Quantifying Potential Genotoxic Compounds with High Resolution LC/MS

| Syed Salman Lateef

Analysis of chlorhexidine drug substance using an Agilent 6545 Accurate Mass Q-TOF System and MassHunter Mass Profiler Software.

Fields & Applications Data Analysis

Enlightened Experimental Design

| Phil Kay

The traditional approach of designing experiments by changing one factor at a time is outmoded.

Techniques & Tools Spectroscopy

Seeing the Full Picture

| Sergei Kazarian

The analytical world in general has yet to appreciate the power of FTIR spectroscopic imaging for process analysis. Here’s why it should be in your toolkit.

Fields & Applications Technology

Absolute molecular weight’s measurements of synthetic polymers using the Viscotek SEC-MALS 20

The molecular weight, molecular weight distribution and size of two common polymers are measured using SEC-MALS 20. Results from SEC-MALS and conventional calibration are compared and discussed.

Techniques & Tools Pharma & Biopharma

Going Further Together

| Deirdre Cabooter

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Fields & Applications Sample Preparation

Analysis of demicellization data from isothermal titration calorimetry

Learn why isothermal titration calorimetry is a method of choice for accurate and precise determination of critical micellar concentration of surfactants for biochemical applications and find out how to analyse demicellization data from Isothermal Titration Calorimetry

Fields & Applications Spectroscopy

Analysis of different of PLA/PLGA polymer samples using a GPC/SEC system

Usually, PLA and PLGA are based on monomers from renewable sources, so are considered “green” polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.

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