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Preparative/Process Chromatography

Techniques & Tools Sample Preparation

Principles of Triple Detection GPC/SEC

| Sponsored by Malvern Panalytical

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also increased amounts of information, which is made available by the combination of different detectors (and unobtainable using individual detectors separately). The theory of triple detection GPC/SEC is described here.

Techniques & Tools Sample Preparation

Using OMNISEC to Understand the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives

| Sponsored by Malvern Panalytical

This application note describes the analyses of a variety of aqueous (water-soluble) cellulose derivatives using the OMNISEC triple detection system and the subtle, yet distinct differences between these different derivatives that can be parsed out by the OMNISEC system

Techniques & Tools Sample Preparation

Characterizing polysaccharide structure with SEC-MALS and intrinsic viscosity measurements

| Sponsored by Malvern Panalytical

In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied.

Techniques & Tools Sample Preparation

Case study of a semi-pure β-amylase extract

| Sponsored by Malvern Panalytical

The investigative power of multiple detectors. Here, we describe the analysis of a semi-purified protein mixture containing β-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how coupling this data can be qualitatively and quantitatively evaluated.

Techniques & Tools Spectroscopy

Countering Counterfeit Medicine Little by Little

| Iestyn Armstrong-Smith

Sulaf Assi is a lecturer in forensic sciences at the Faculty of Science and Technology at Bournemouth University, UK.

Techniques & Tools Mass Spectrometry

Digging into Biomarkers of Oxidative Stress

| Michael Lämmerhofer

Hyphenated chromatography techniques enable the selection of representative biomarkers of oxidative stress – and help resolve the huge complexity of lipid oxidation products.

Techniques & Tools Pharma & Biopharma

Finding Humanity in Science

| Rich Whitworth

What drives someone to throw aside selfish pursuits to focus on projects with true philanthropic impact? Here, the winners of the 2015 Humanity in Science Award provide their answers.

Techniques & Tools Preparative/Process Chromatography

The (not so) EZ Journey to Improved GC Methods

| Jaap de Zeeuw, Jack Cochran

In 2014, The Analytical Scientist Innovation Awards recognized our new and simplified EZGC® method development software. Here, we explore the complex roots that led to its creation.

Techniques & Tools Pharma & Biopharma

PREP Preview

| Rich Whitworth

Two advances in (bio)pharmaceutical manufacture that aim to democratize the gift of medicine

Techniques & Tools Liquid Chromatography

Remembering Georges Guiochon

| Pat Sandra, Barry Karger, Peter Schoenmakers, Attila Felinger, Wolfgang Lindner

“One of the giants of separation science,” Georges Guiochon (1931–2014) will certainly be missed. Equally certainly, he will continue to inspire and educate future generations. Here, seven friends, colleagues and collaborators remember Georges with great fondness.

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