Sample Preparation

In this white paper we examine the deformulation workflow, demonstrating the value of the technique of Morphologically Directed Raman Spectroscopy (MDRS) within this context. Case studies illustrate the relevance of MDRS data.

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides practical guidance on how imaging can be applied as a routine method to robustly identify and quantify the state of agglomeration of pharmaceutical formulations.

In 2014, Select-eV took a top spot in The Analytical Scientist Innovation Awards (TASIAs). Here, the technology is teamed up with (GC×GC)-MS in an unusual international environmental monitoring project.

In some industries, for example, in early-stage pharmaceutical development, it is desirable to measure particle size from a small samples of dry powders. However measuring small quantities risks measuring a sample that is not representative of the bulk material. In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.

This application note discusses the methodology and results for the rheological characterization of Opthalmic Viscosurgical Devices (OVDs) according to the International Standard ISO15798:2013

Using OMNISEC, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.

Let’s go back to the early 1990s when an important innovation was starting to cause a stir. Electrospray ionization (ESI) essentially allowed liquid chromatography (LC) and mass spectrometry (MS) to be combined much more easily as an analytical technique.

Wolfgang discusses the spirit of science, Salzburg and ISC2014 in the latest episode of Tea with Rich.

There are a lot of things to consider when seeking good results from gas chromatography. Success often comes from understanding precisely what goes on in the injection port.

A concern raised by the rise in routine MRI screening within the healthcare industry is that the ability to detect abnormalities within the body may currently be running ahead of our understanding of their possible consequences, making it difficult to determine a sound course of action. Here then analytical science is arguably advancing beyond current requirements.