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Sample Preparation

Fields & Applications Sample Preparation

The big reveal: Workhorse + Innovation = more information (Part 2)

In this second article of a short series Dr Paul Kippax is looking at the how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of multiple detectors to a GPC/SEC analysis…

Techniques & Tools Sample Preparation

The big reveal: Workhorse + Innovation = more information (Part3)

| Sponsored by Malvern Panalytical

In this short series of articles Dr Paul Kippax is looking at how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of Raman spectroscopy to automated imaging…

Techniques & Tools Sample Preparation

GPC/SEC analysis of polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA) using OMNISEC

| Sponsored by Malvern Panalytical

In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.

Fields & Applications Sample Preparation

Measuring protein molecular weight using the Viscotek SEC-MALS 20 connected to a Waters Empower® SEC system

In this application note, we show that Malvern’s OmniSEC software can now communicate with Waters Empower® for the seamless exchange of sample sequences. A selection of proteins was used to demonstrate the measurement of protein molecular weight, oligomeric and aggregation state.

Fields & Applications Sample Preparation

PEGylated proteins: Optimizing conjugation reactions using triple detection SEC

In this application note, one protein, interferon α-5, was conjugated with two different PEG molecules in different reactions.  The protein and PEG molecules were characterized individually using multi-detector SEC, followed by the PEGylated conjugates.  Their composition, molecular weights and intrinsic viscosities were measured. This work was performed by Celares GMBH, Germany with samples provided by DIGNA BIOTECH, Spain

Techniques & Tools Technology

Return of the TASIAs

| Rich Whitworth

Accurate measurement drives progress in science in immeasurable ways. Here, we celebrate a year’s worth of advances in The Analytical Scientist Innovation Awards 2014. What impact will these 15 TASIA winners have on your field?

Techniques & Tools Sample Preparation

What You’ve Been Reading...

| Rich Whitworth

We dived into our analytics to find the most popular online articles. Here, we present a thought-provoking quote from each of the top ten.

Techniques & Tools Mass Spectrometry

The Coffee-ring Effect

| Bob Blackledge

A single photo got me thinking about sample preparation for mass spectrometry – that’s the real beauty of art.

Techniques & Tools Sample Preparation

Tea With Pat Sandra

| Pat Sandra, Rich Whitworth

Rich invites Pat to chat about the prestigious Pregl Medal and more at ISC2014 in Salzburg

Fields & Applications Sample Preparation

Application of Dynamic Light Scattering to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 4. FAQs

Frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations

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