Technology

In this application note we will look at two examples where the retention volume of a sample could not be used to obtain an accurate measure of the sample MW. We will also describe the additional information that can be obtained using these advanced detectors. This work has been performed in conjunction with the Institut Pasteur, Paris, France

The aim of this guide is to provide the reader with a clear understanding of the different technological approaches used to measure molecular weight by static light scattering in a GPC/SEC experiment.

Work performed in conjunction with the Membrane Protein Laboratory, Imperial College, London

Light scattering detectors play an important role in gel permeation chromatography and size exclusion chromatography (GPC/SEC) analysis because of their ability to directly measure molecular weight distribution. Multi angle light scattering (MALS) detectors are often chosen, in some instances because they provide the most accurate data for the measurement of the radius of gyration (Rg), and in others because they have become an accepted industry standard. The launch of Malvern Instruments’ new Viscotek SEC-MALS 20 detector extends commercial choice in this area and draws the technology into the spotlight.

When and where should we apply the concept of “just enough is best”?

Carbon black nanoreporters can warn oil producers of unacceptable levels of hydrogen sulfide

Two-dimensional liquid chromatography certainly sounds impressive and produces some pretty pictures, but is it essential in the analysis of complex samples? Here, we show that 2D-LC offers both style and substance.

A multitude of wearable biosensors for monitoring our personal health and the external environment are on the way, led by technologies to improve performance in sport and all-round fitness. They are easy to use, will cost little and provide useful, real-time information. Stand by for the democratization of analysis.

Dwight Stoll has been working in 2D-LC since 2000. Here, he talks about the benefits of what is a core technology in his research.

Moving from 1D to 2D liquid chromatography is a big step towards the high peak capacities demanded by complex sample analysis.