The Analysis of Urine for Trace Elements using the NexION 2000 ICP-MS
contributed by Perkin Elmer |
Introduction
The determination of trace elements in biological fluids presents a challenge for a number of reasons, including the complex nature of the matrices and the widely varying concentrations of the metals which are present. Among the most commonly analyzed biological fluids (urine, blood, serum), urine is unique in that its main function is waste removal from biological systems. As a result, urine is composed of a complex mixture of components which can vary widely between samples and can be affected by food, environmental, and industrial exposures. For these reasons, both matrix and analyte levels of urine often vary significantly between samples, posing a challenge for analysis.
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