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Fields & Applications

Fields & Applications Forensics

Quis Custodiet Ipsos Custodes

| Clifford Spiegelman, William Tobin

Conducting an autopsy of the flaws of comparative bullet lead analysis in forensic practice

Fields & Applications Spectroscopy

A Light Boost for Water Treatment

| Victoria Barton

Exploring fluorescence spectroscopy’s ability to monitor quality – and reduce operating costs in wastewater treatment works

Fields & Applications

Tomorrow Never Knows

| Rich Whitworth

“Turn off your mind, relax and float downstream...” The Power List is shining, it is shining.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 4

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 3

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 2

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 1

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part One, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.

Fields & Applications Pharma & Biopharma

Using Raman Spectroscopy to Understand the Conformational Stability of Protein Therapeutics

Use of a novel combination of dynamic light scattering and Raman spectroscopy to elucidate the conformational stability and structure of proteins in biopharmaceutical formulations

Fields & Applications Sample Preparation

Nanoparticle Tracking Analysis: Drug nanocarriers

The role that nanoparticles play in the rapidly developing field of ‘NanoMedicine’ has been discussed previously in Chapter 5. In this Chapter, we review the specific mechanisms by which such nanoparticles are designed and formulated and in which NTA has had a significant part to play.

Fields & Applications Sample Preparation

Monitoring the particle size distribution of ground coffee

The ability to quickly and reproducibly measure coffee ground particle size and size distributions is important during grinding operations to ensure that the coffee quality is maintained and that the correct grade is produced. The Mastersizer 3000 and the Funnel Sample Feeder for the Aero S dry powder disperser provides this capability, offering a rapid alternative to traditional sieve analysis.

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