Fields & Applications

An ambitious UK sequencing project aims to learn more about patients with cancer and rare diseases

A concern raised by the rise in routine MRI screening within the healthcare industry is that the ability to detect abnormalities within the body may currently be running ahead of our understanding of their possible consequences, making it difficult to determine a sound course of action. Here then analytical science is arguably advancing beyond current requirements.

Odorant binding proteins could help to unlock new biosensors

In this second article of a short series Dr Paul Kippax is looking at the how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of multiple detectors to a GPC/SEC analysis…

Turn your smartphone into a portable fluorescence microscope for imaging and sizing DNA molecules

Combining art and science is becoming a bit of a theme for The Analytical Scientist. Lewis Carroll’s reference to stereoisomers sent me down my own rabbit hole of discovery.

In this application note, we show that Malvern’s OmniSEC software can now communicate with Waters Empower® for the seamless exchange of sample sequences. A selection of proteins was used to demonstrate the measurement of protein molecular weight, oligomeric and aggregation state.

In this application note, one protein, interferon α-5, was conjugated with two different PEG molecules in different reactions.  The protein and PEG molecules were characterized individually using multi-detector SEC, followed by the PEGylated conjugates.  Their composition, molecular weights and intrinsic viscosities were measured. This work was performed by Celares GMBH, Germany with samples provided by DIGNA BIOTECH, Spain

The M908 took the top spot in our 2013 Innovation Awards – “Revolutionary technology; will be an inspiration for new generations,” said the judges. Here, four co-founders of 908 Devices describe the perfect storm that led to the creation of the world’s first handheld mass spectrometer.

Will the future see crime scene investigators collecting nasal swabs or rinses from deceased victims to identify the assailant? In a word: yes.