Liquid Chromatography

In water analysis, direct injection of samples into your LC-MS/MS system (without sample preparation beyond filtration) is possible because of advances in instrumentation. However, matrix effects must be monitored carefully – and sometimes may even prove useful.

This short and seemingly simple question belies the complexity of measuring – and interpreting – pH.

Can multi-angle light scattering aid in the characterization of proteins and antibody drug conjugates?

Could carbon nanotubes hold the key to real-time, portable testing for meat freshness?

A new LC-MS/MS screening method simultaneously detects a wide range of non-banned potentially performance enhancing drugs and masking agents in urine

Selecting “the paper of the year” is by definition subjective and very personal.

Can R&D organizations really afford to kill off analytical data that could be used for future decision-making? Perhaps it’s time to breathe life back into analytical data environments.

The juxtaposition of simplicity through new technology with complexity in the chemistry keeps gas chromatographic method development exciting – despite GC being described by many as a “mature” technique. But are we still using packed-column thinking?

Just imagine how many analytical problems would be solved if we could increase the resolution of liquid chromatography (LC) from hundreds to thousands or perhaps a hundred thousand compounds?

Online hyphenation of capillary electrophoresis and mass spectrometry is nearly 30 years old, but has been ignored in certain camps. It’s time to give CE-MS a chance.