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Techniques & Tools Metabolomics & Lipidomics, Gas Chromatography, Liquid Chromatography, Mass Spectrometry

Standing Up for GC-MS – and Good Science

Mingliang Fang’s paper in Analytical Chemistry, “Thermal Degradation of Small Molecules: A Global Metabolomic Investigation” (1), has been producing significant controversy since its appearance – and the paper’s conclusions are upsetting many people. Fang’s paper queries the entire concept of gas-chromatography mass spectrometry – a methodology used routinely in metabolomic investigations. By heating samples in a mimic of GC separation (GC generally uses a heat gradient to separate biomolecules) or derivitization followed by liquid chromatography, they observed significant changes in the metabolic profile observed – breakdown of triphosphates to monophosphates, for example.

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About the Author

Karl Burgess

Karl Burgess is Head of Metabolomics at Glasgow Polyomics, University of Glasgow, Scotland.

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