Liquid Chromatography

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also increased amounts of information, which is made available by the combination of different detectors (and unobtainable using individual detectors separately). The theory of triple detection GPC/SEC is described here.

This application note describes the analyses of a variety of aqueous (water-soluble) cellulose derivatives using the OMNISEC triple detection system and the subtle, yet distinct differences between these different derivatives that can be parsed out by the OMNISEC system

In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied.

Analysis of chlorhexidine drug substance using an Agilent 6545 Accurate Mass Q-TOF System and MassHunter Mass Profiler Software.

Two-dimensional mass spectrometry (2DMS) can be twice as fast as conventional methods in proteomic analyses

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Continual advances in liquid chromatography have raised the bar from high performance to ultra-high performance, resulting in increased analytical, instrument, and laboratory efficiency. What’s holding you back from investments in UHPLC technology?

The Analytical Scientist Innovation Awards (TASIAs) return for a third consecutive year to recognize 12 months of innovation from companies big and small.

In water analysis, direct injection of samples into your LC-MS/MS system (without sample preparation beyond filtration) is possible because of advances in instrumentation. However, matrix effects must be monitored carefully – and sometimes may even prove useful.

This short and seemingly simple question belies the complexity of measuring – and interpreting – pH.