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Microscopy

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 3

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 2

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

Fields & Applications Sample Preparation

Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on a filter membrane.

Fields & Applications Sample Preparation

Microcalorimetry as a tool for structural biology

Learn how Isothermal titration calorimetry can be used to guide protein (RNA)/ligand crystallization and to resolve common issues with crystallization of complexes.

Fields & Applications Sample Preparation

Characterization of IgG monomers & their aggregates

Determining the components, and their proportion, in a protein sample is essential for the improvement of candidate formulations and characterization of final formulations.

Techniques & Tools Microscopy

When Art Meets Science

| Frank van Geel

Welcome to our second foray into the fascinating confluence of aesthetics and analytics, where we celebrate the wonderful and diverse world of analytical science by sharing your spectacular images.

Techniques & Tools Spectroscopy

Unraveling Art with Analysis

| Stephanie Sutton

SORS meets microscopy to delve deeper into historical art and sculptures

Techniques & Tools Microscopy

Rewarding Lab Effectiveness and Efficiency

| Peter James

S-Lab is using an awards scheme, an annual conference, and assessment tools and guidance to drive improvement in areas that are common to both analytical and research laboratories.

Techniques & Tools Technology

The Big Picture

| Rich Whitworth

In the quest for increased sensitivity or higher resolution, let’s not lose sight of our objectives.

Fields & Applications Sample Preparation

Detecting agglomerates within pharmaceutical formulations

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides practical guidance on how imaging can be applied as a routine method to robustly identify and quantify the state of agglomeration of pharmaceutical formulations.

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