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Microscopy

Techniques & Tools Forensics

Forensic Myths and Methods

| Glen Jackson, Christopher Palenik

Don your purple nitrile gloves and grab a swab or two, as we delve into the realities of crime scene investigation.

Techniques & Tools Sample Preparation

Principles of Triple Detection GPC/SEC

| Sponsored by Malvern Panalytical

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also increased amounts of information, which is made available by the combination of different detectors (and unobtainable using individual detectors separately). The theory of triple detection GPC/SEC is described here.

Techniques & Tools Spectroscopy

Seeing the Full Picture

| Sergei Kazarian

The analytical world in general has yet to appreciate the power of FTIR spectroscopic imaging for process analysis. Here’s why it should be in your toolkit.

Techniques & Tools Microscopy

Supercharging Correlative Microscopy

| Olaf Hollricher

Equipping scanning electron microscopes with Raman imaging to create a 2014 Innovation Award-winning universal microscopy solution.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 4

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 3

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 2

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

Fields & Applications Sample Preparation

Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on a filter membrane.

Fields & Applications Sample Preparation

Microcalorimetry as a tool for structural biology

Learn how Isothermal titration calorimetry can be used to guide protein (RNA)/ligand crystallization and to resolve common issues with crystallization of complexes.

Fields & Applications Sample Preparation

Characterization of IgG monomers & their aggregates

Determining the components, and their proportion, in a protein sample is essential for the improvement of candidate formulations and characterization of final formulations.

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