Metabolomics & Lipidomics

Richard D. Smith reflects on 40 years in mass spectrometry following his Distinguished Contribution award at ASMS 2013.

An integrated approach to uncovering distinct metabolite profile shifts in diabetes progression. The prevalence of type 2 diabetes mellitus (T2DM) is on a rampant rise across the globe, making it a critical area of study for metabolomics and biomarker discovery.

Generating robust biomolecular signatures from diabetic wound fluid

Researchers tackle elucidation of sulfur-containing metabolites in plant extracts with Fourier ... transform mass spectrometry

Three gurus describe significant breakthroughs in micro and nanoscale analytical techniques and envisage where they might take us next.

Introduced by Robert Guthrie in the 1960s, dried blood spot (DBS) sampling involves taking small drops ... of blood from either a finger prick (or heel prick in neonates) and depositing them on specially manufactured absorbent card where they are allowed to dry. Once dry, DBS cards can be readily transported by post for analysis since the components of the blood remain unchanged for several days, even at room temperature. For analysis, a portion of the blood spot is removed from the card and placed in a solvent to extract the analyte(s) of interest.

Dried Blood Spot (DBS) sampling is being adopted in drug development, paediatric healthcare, and, more recently, patient compliance.

The integration and application of powerful post-genomic technologies is required for food scientists to meet their latest challenges.

Two new studies demonstrate the power of advanced metabolomics; progress in …