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Sample Preparation

Techniques & Tools Clinical

Meet The Cannabis Scientist…

| Rich Whitworth

…our ‘mini magazine’ dedicated to medical cannabis

Business & Education Sample Preparation

Why should I upgrade to multi-detection GPC?

| Sponsored by Malvern Panalytical

10 reasons for polymer characterization scientists. Gel-permeation chromatography (GPC) is an essential tool for the characterization of polymers. It allows polymer scientists to tailor a polymer’s properties to its end use requirements by controlling its molecular properties, since the two are inextricably linked.

Business & Education Sample Preparation

Assessing Nanoparticle Toxicity in Waste Water

| Sponsored by Malvern Panalytical

Nanoparticle Tracking Analysis (NTA) has found use in a variety of investigations researching the toxicity and environmental impact of nanoparticles. Here we discuss various publications in which NTA has been used to measure particle size and concentration of nanomaterials in waste water.

Techniques & Tools Business

Sample Prep, Screening and Software in the Cloud

| Rich Whitworth, Marcus Lippold

Products, partnerships, investments - what’s going on in the analytical science business world.

Business & Education Sample Preparation

Characterizing method for polymers

| Sponsored by Malvern Panalytical

This whitepaper reviews the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation / size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the principles discussed are equally applicable to proteins or protein conjugate materials.

Techniques & Tools Sample Preparation

Solvent Enhanced Light Scattering of Fluoro-Polyester

| Sponsored by Malvern Panalytical

Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.

Business & Education Sample Preparation

Detection and quantification of large protein aggregates

| Sponsored by Malvern Panalytical

The complementarities of two techniques, dynamic light scattering (DLS) and static light scattering detector coupled with a size exclusion chromatography system (SEC-LS), are illustrated by studying a number of samples where a thermally denatured and aggregated protein sample were dosed at different levels into a non-denatured protein sample.

Business & Education Sample Preparation

Intrinsic viscosity measurements on sRAGE protein

| Sponsored by Malvern Panalytical

In this application note, intrinsic viscosity measurements were performed on the sRAGE protein to establish whether the detector was able to detect and characterize the conformational change induced by the presence of calcium. Light scattering molecular weight measurements were also performed. Data are also presented showing that the conformation of sRAGE changes in the presence and absence of calcium.

Techniques & Tools Liquid Chromatography

Splendid Isolation

| Sebastian Pantò

A new instrument could help with obtaining pure components from complex natural samples.

Techniques & Tools Sample Preparation

The Benefits of Multi-Detector SEC for Protein Analysis'

| Sponsored by Malvern Panalytical

This article explores how multiple detectors, particularly light scattering detectors, may be used for size-exclusion chromatography (SEC) in protein analysis. Using a light scattering detector as part of a multi-detector Size Exclusion Chromatography system provides the accurate molecular weight (MW) data needed to assess the activity, safety and clinical efficacy of therapeutic proteins.

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