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January 2016 Issue of The Analytical Scientist

Welcome to January's issue! In Upfront, “Making a Murderer” raises the profile of analytical chemists, researchers puncture claims that banned tire treatments are undetectable, and genomics rules the roost in Thomas Reuters’ “hottest researchers”. We Sit Down With Carlo Bicchi, and Philip Britz-McKibbin asks if there’s a simpler method for multiplexed separations in metabolomics. In ‘Exploring Our Blue Planet’, oceanographer Rob Munier explains the role of analytical science in understanding the mysteries of the deep. And from our blue planet to the red planet, we talk to two experts who are looking to Mars to learn more about the universe.

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Articles featured in this issue

Techniques & Tools Data Analysis

Nice Measurement – Now What?!

| Rich Whitworth

Concerning disparity between measurements and decisions.

Techniques & Tools Technology

SERS SLIPS Ahead

| Tak Sing Wong

Can a new slippery surface for Raman scattering open the door to routine single molecule detection?

Fields & Applications Mass Spectrometry

Characterizing Collagen at the Double

| James Strachan

Two-dimensional mass spectrometry (2DMS) can be twice as fast as conventional methods in proteomic analyses

Techniques & Tools Data Analysis

Faster (GC) Tactics

| Jaap de Zeeuw

Five ways to speed up gas chromatography analyses using your current system

Fields & Applications Materials

Gene Genie

Genomics platform director tops Thomson Reuters’ list of highly cited authors

Fields & Applications Forensics

Making a Murderer

| James Strachan

Analytical science hits the mainstream with Netflix’s hit documentary [spoiler alert!]

Techniques & Tools Mass Spectrometry

End of the Road

| James Strachan

Researchers use SPME and GC-MS to puncture claims that banned tire treatments are “undetectable”

Fields & Applications Technology

Image of the Month

| Rich Whitworth

Benthoctopus sp gets overly familiar with Alvin’s robotic manipulator arm at 2,300 meters down in the Gulf of Mexico.

Techniques & Tools Spectroscopy

Seeing the Full Picture

| Sergei Kazarian

The analytical world in general has yet to appreciate the power of FTIR spectroscopic imaging for process analysis. Here’s why it should be in your toolkit.

Fields & Applications Mass Spectrometry

A Tiny Sample Problem

| Rawi Ramautar

A novel CE-MS technique shows great promise for sample-restricted metabolomics.

Fields & Applications Mass Spectrometry

MSI-CE-MS Simplifies Separations

| Philip Britz-McKibbin

Multiplexed separations in metabolomics: is there a faster, cheaper, and better way?

Fields & Applications Data Analysis

Enlightened Experimental Design

| Phil Kay

The traditional approach of designing experiments by changing one factor at a time is outmoded.

Techniques & Tools Mass Spectrometry

Exploring Our Blue Planet

| Rob Munier

The seven seas represent an extremely challenging and almost boundless environment that a secret army of passionate oceanographers nevertheless joyfully dive into.

Fields & Applications Spectroscopy

Exploring the Red Planet

| Roger Wiens

Scientists who are dissatisfied with the analysis of samples from our blue planet look to the stars

Fields & Applications Spectroscopy

Dating in Space

| F. Scott Anderson

F. Scott Anderson, a staff scientist at the Southwest Research Institute, Boulder, Colorado, USA, discusses the potential of in-situ resonance ionization mass spectrometry for understanding the age of planetary bodies.

Techniques & Tools Technology

Faster Chemical Separations

| Lukas Märk

A 2015 Innovation Award-winning “fastGC” module enhances proton transfer reaction time-of-flight analyzer performance by adding an optional near real-time chemical pre-separation step. Here’s the story behind its development.

Techniques & Tools Gas Chromatography

Applying the Basics

| Carlo Bicchi

Sitting Down With… Carlo Bicchi, Professor of Pharmaceutical Biology at the University of Turin, and member of the scientific committee for the 40th International Symposium on Capillary Chromatography and 13th GC×GC Symposium (Riva 2016), Italy.

Techniques & Tools Mass Spectrometry

Screening, Identifying, and Quantifying Potential Genotoxic Compounds with High Resolution LC/MS

| Syed Salman Lateef

Analysis of chlorhexidine drug substance using an Agilent 6545 Accurate Mass Q-TOF System and MassHunter Mass Profiler Software.

Techniques & Tools Technology

Dioxin Determination in Air Filter Samples Using Pressurized Solvent Extraction (PSE)

| Sponsored by Buchi

Extraction of air sampling filters for the determination of dioxins using BUCHI’s SpeedExtractor E-914

Fields & Applications Spectroscopy

Small-footprint Absorbance System for Characterizing Heme Proteins

| Yvette Mattley

Compact Spark spectral sensor measures Vis-NIR absorbance of hemoglobin – and more

Fields & Applications Gas Chromatography

GC-MS and the Art of POP Analysis

| Esteban Abad Holgado

Persistent organic pollutants (POPs) encompass a wide variety of contaminants, but they share one thing in common: they have the potential to hit headlines and cause huge disruption to the food and feed industry.

Techniques & Tools Mass Spectrometry

Talking Extractables & Leachables testing using Orbitrap based mass spectrometry

| Kate Comstock

Hear from Kate Comstock as she talks about her long experience with extractables testing in pharmaceutical companies

Techniques & Tools Gas Chromatography

Talking Extractables & Leachables – no more unknowns?

| Kyle D’Silva

Hear from Kyle D’Silva as he discusses new developments in GC-MS technology for Extractables and Leachables testing

Techniques & Tools Technology

Tea With Monika Dittman

| Monika Dittmann

Monika Dittman joins Rich Whitworth for tea in Geneva and once again “surfs” the limits of liquid chromatography.

Techniques & Tools Clinical

Tea With Michal Holcapek

| Michal Holcapek

Michal discusses the differences between theory and application and gives his own work in advanced lipidomics and the different demands of clinical analysis as an example.

Other issues of 2016