Data Analysis

Other techniques are beating chromatography and mass spectrometry to the hero’s reward all too often. Are they better? No. Are they faster to first result? Yes. Is it time to acknowledge that – on the frontlines – fit-for-purpose triumphs over best-in-class? You decide.

To make way for more flexible approved analytical methods, we need a better understanding of the underlying scientific principles.

Turn your smartphone into a portable fluorescence microscope for imaging and sizing DNA molecules

In this application note, we show that Malvern’s OmniSEC software can now communicate with Waters Empower® for the seamless exchange of sample sequences. A selection of proteins was used to demonstrate the measurement of protein molecular weight, oligomeric and aggregation state.

In this application note, one protein, interferon α-5, was conjugated with two different PEG molecules in different reactions.  The protein and PEG molecules were characterized individually using multi-detector SEC, followed by the PEGylated conjugates.  Their composition, molecular weights and intrinsic viscosities were measured. This work was performed by Celares GMBH, Germany with samples provided by DIGNA BIOTECH, Spain

A technique can only make it into the upper echelons of analytical chemistry with a strong, balanced team. And that means bringing together fundamental researchers, application specialists, and instrumentation experts on a well-supported playing field.

We dived into our analytics to find the most popular online articles. Here, we present a thought-provoking quote from each of the top ten.

How to use a knowledge repository that doesn’t retire or leave you for a competitor.

Frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of hexafluoroisopropanol (HFIP) as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and safety.