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Data Analysis

Fields & Applications Sample Preparation

Applications of Isothermal Titration Calorimetry and differential scanning calorimetry in biopharmaceutical

This application note presents an example of how calorimetry aided the formulation development for ProX by providing insight into excipient-protein interactions. Polysorbate-80 and phenol are examined here as potential additives to the formulation buffer for ProX.

Fields & Applications Technology

Exosomes and Microvesicles: An introduction

The study of exosomes and other cell-derived microvesicles is an area of rapidly rowing importance and the subject of intense interest and research. The previous lack of suitable methods for their detection, analysis, enumeration and phenotyping is proving to be a significant limitation in these studies. This document shows the degree to which the technique of Nanoparticle Tracking Analysis (NTA) is helping to address these problems.

Fields & Applications Sample Preparation

Beyond SOPs – Exploring the Rigor and Requirements of Analytical QbD

Analytical QbD (AQbD) promises to extend the rigor and benefits of QbD into the area of analytical method development.

Techniques & Tools Mass Spectrometry

Extreme Environments

Over the past few months, we’ve been asking you to send in the photos and images that best reflect the important and intriguing work that you do.

Techniques & Tools Food, Beverage & Agriculture

Tea With Rich...

| Rich Whitworth

Whilst at Riva 2014 (the 38th ISCC and 11th GCxGC Symposium), Rich Whitworth, editor of The Analytical Scientist, invited three key participants of the conference to take part in an exciting new video projec

Fields & Applications Sample Preparation

10 Reasons that the Zetasizer Nano is chosen for scientific success

New components and measurement techniques continue to be introduced for the Zetasizer Nano. New to the system are a Surface Zeta Potential accessory and a new diffusion barrier method for improved zeta potential measurements of protein samples. Why is the Malvern Zetasizer Nano so popular and found in a broad range of applied and fundamental scientifi c projects across all industries and fields? Because, it is simply the most dynamic and broad ranged instrument on the market for solving technical issues in today’s research environment and it continues to evolve with new capabilities. Here are 10 reasons why you should choose the Zetasizer Nano:

Fields & Applications Sample Preparation

Automated particle size with Zetasizer NanoSampler

The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano for particle size measurements. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano.

Fields & Applications Sample Preparation

Differentiation and characterization of subvisible particulates in therapeutic protein products

This application note provides an example of how Archimedes can be used to detect and quantify the formation of protein sub-visible particles and the introduction of silicone oil droplets, in response to shear stress.

Fields & Applications Data Analysis

Targeting the Untargeted

| John A. McLean

Our capacity to generate data is unsurpassed, but how do we cope with the data deluge? It’s time to embrace data-driven discovery in biology and medicine.

Techniques & Tools Technology

Command the Box

| Bill Anderson

Surely, we’ve gone beyond thinking outside the box – the time has come to tell the box to respond to our thoughts.

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