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Data Analysis

Fields & Applications Sample Preparation

The big reveal: Workhorse + Innovation = more information (Part 1)

A concern raised by the rise in routine MRI screening within the healthcare industry is that the ability to detect abnormalities within the body may currently be running ahead of our understanding of their possible consequences, making it difficult to determine a sound course of action. Here then analytical science is arguably advancing beyond current requirements.

Fields & Applications Sample Preparation

The big reveal: Workhorse + Innovation = more information (Part 2)

In this second article of a short series Dr Paul Kippax is looking at the how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of multiple detectors to a GPC/SEC analysis…

Techniques & Tools Sample Preparation

The big reveal: Workhorse + Innovation = more information (Part3)

| Sponsored by Malvern Panalytical

In this short series of articles Dr Paul Kippax is looking at how recent innovations are substantially enhancing the value and informational productivity of some of our established and trusted analytical techniques. This time, the addition of Raman spectroscopy to automated imaging…

Techniques & Tools Sample Preparation

GPC/SEC analysis of polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA) using OMNISEC

| Sponsored by Malvern Panalytical

In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.

Techniques & Tools Mass Spectrometry

Chromatography: Winning Every Battle, Losing the War?

| Hans-Gerd Janssen

Other techniques are beating chromatography and mass spectrometry to the hero’s reward all too often. Are they better? No. Are they faster to first result? Yes. Is it time to acknowledge that – on the frontlines – fit-for-purpose triumphs over best-in-class? You decide.

Techniques & Tools Data Analysis

Making Room for Improvement

| Dennis Åsberg

To make way for more flexible approved analytical methods, we need a better understanding of the underlying scientific principles.

Fields & Applications Data Analysis

DNA Imaging On-the-Go

| Stephanie Vine

Turn your smartphone into a portable fluorescence microscope for imaging and sizing DNA molecules

Fields & Applications Sample Preparation

Measuring protein molecular weight using the Viscotek SEC-MALS 20 connected to a Waters Empower® SEC system

In this application note, we show that Malvern’s OmniSEC software can now communicate with Waters Empower® for the seamless exchange of sample sequences. A selection of proteins was used to demonstrate the measurement of protein molecular weight, oligomeric and aggregation state.

Fields & Applications Sample Preparation

PEGylated proteins: Optimizing conjugation reactions using triple detection SEC

In this application note, one protein, interferon α-5, was conjugated with two different PEG molecules in different reactions.  The protein and PEG molecules were characterized individually using multi-detector SEC, followed by the PEGylated conjugates.  Their composition, molecular weights and intrinsic viscosities were measured. This work was performed by Celares GMBH, Germany with samples provided by DIGNA BIOTECH, Spain

Techniques & Tools Data Analysis

The Champions League of Measurement Science

| Peter Schoenmakers

A technique can only make it into the upper echelons of analytical chemistry with a strong, balanced team. And that means bringing together fundamental researchers, application specialists, and instrumentation experts on a well-supported playing field.

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