Sample Preparation

This article explains how an inline probe was used to monitor a granulation at three different scales to confirm that, in each case, the granules produced were the same size, and more importantly produced tablets of identical quality as quantified by hardness.

The particle size of the fat droplets present in dairy and other food emulsions is important in defining properties such as flavor release, mouth feel and emulsion stability. Thus, a knowledge of the particle size is critical in defining the functionality and taste of different food emulsion products. Here we show how laser diffraction can be used to measure and understand the changes in size that occur during production and storage of dairy products. This in turn can lead to a better understanding of how product formulation and performance are linked.

Quantifying Nanoparticle Concentration and Size to Optimize Filtration Processes

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10 reasons for polymer characterization scientists. Gel-permeation chromatography (GPC) is an essential tool for the characterization of polymers. It allows polymer scientists to tailor a polymer’s properties to its end use requirements by controlling its molecular properties, since the two are inextricably linked.

Nanoparticle Tracking Analysis (NTA) has found use in a variety of investigations researching the toxicity and environmental impact of nanoparticles. Here we discuss various publications in which NTA has been used to measure particle size and concentration of nanomaterials in waste water.

Products, partnerships, investments - what’s going on in the analytical science business world.

This whitepaper reviews the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation / size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the principles discussed are equally applicable to proteins or protein conjugate materials.

Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.

The complementarities of two techniques, dynamic light scattering (DLS) and static light scattering detector coupled with a size exclusion chromatography system (SEC-LS), are illustrated by studying a number of samples where a thermally denatured and aggregated protein sample were dosed at different levels into a non-denatured protein sample.