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Data Analysis

Techniques & Tools Sample Preparation

Characterizing polysaccharide structure with SEC-MALS and intrinsic viscosity measurements

| Sponsored by Malvern Panalytical

In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied.

Techniques & Tools Sample Preparation

Case study of a semi-pure β-amylase extract

| Sponsored by Malvern Panalytical

The investigative power of multiple detectors. Here, we describe the analysis of a semi-purified protein mixture containing β-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how coupling this data can be qualitatively and quantitatively evaluated.

Fields & Applications Data Analysis

Enlightened Experimental Design

| Phil Kay

The traditional approach of designing experiments by changing one factor at a time is outmoded.

Techniques & Tools Data Analysis

Faster (GC) Tactics

| Jaap de Zeeuw

Five ways to speed up gas chromatography analyses using your current system

Techniques & Tools Data Analysis

Nice Measurement – Now What?!

| Rich Whitworth

Concerning disparity between measurements and decisions.

Fields & Applications Technology

Absolute molecular weight’s measurements of synthetic polymers using the Viscotek SEC-MALS 20

The molecular weight, molecular weight distribution and size of two common polymers are measured using SEC-MALS 20. Results from SEC-MALS and conventional calibration are compared and discussed.

Fields & Applications Sample Preparation

Analysis of demicellization data from isothermal titration calorimetry

Learn why isothermal titration calorimetry is a method of choice for accurate and precise determination of critical micellar concentration of surfactants for biochemical applications and find out how to analyse demicellization data from Isothermal Titration Calorimetry

Fields & Applications Spectroscopy

Analysis of different of PLA/PLGA polymer samples using a GPC/SEC system

Usually, PLA and PLGA are based on monomers from renewable sources, so are considered “green” polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.

Fields & Applications Spectroscopy

Using OMNISEC Triple-Detection GPC to Determine Structure of Dextrans and Other Polysaccharides

This application note will describe the analysis of a series of dextran samples ranging in molecular weight from about 1 – 650 kDa. Structural comparisons to other polysaccharides, gum arabic and pectin are presented. Initially discovered by Louis Pasteur in 1861, dextran is a polysaccharide that has found a variety of applications, primarily in the medical field, due to its minimal side-effects and solubility in aqueous media.

Techniques & Tools Data Analysis

The Drug Concentration Conundrum

| Marcel Florin Musteata

When it comes to measuring drugs in biological samples, what is needed, what is quantifiable – and what role should analytical scientists really be playing?

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